RetroArch
is the Frontend of LibRetro.
It generally has slightly out of date versions, but sometimes they have continued progress in otherwise abandoned emulators.
Bizhawk
has some out of date cores, but some cores are Original.
It's mostly focused for the creation of Tool Assisted Speedruns (TAS), but can be used for casual play.
Mednafen
has some out of date cores, but some cores are Original.
Since it's commandline for loading games, you can use Mednaffe as GUI.
MAME
is mostly focused on Arcade machines, with some good Home Console drivers.
An alternative GUI is pfeMAME.
Using it on RetroArch is... complicated.
FinalBurn Neo
is also focused on Arcade machines, with few Home Consoles.
Has more "Quality of Life" improvements compared to MAME, while being very similar in accuracy.
ares
is the succesor of higan, which is the superset of bsnes.
Most cores are original, with the oldest being the more accurate ones.